CUSTOM ITEM: Guard Column cartridge, Bidentate C8, replacement, 4.0 mm ID x 10 mm long cartridge packed with 5 um, 300 A phase. Cogent TYPE-C Brand. 1 EA.
Additional Info:
The 40008‑PG6‑3 Cogent Bidentate C8 Guard Column Cartridge is a single replacement cartridge designed to protect standard‑flow analytical HPLC columns during wide‑pore (300 Å) separations, especially for larger molecules and complex sample matrices.
Each cartridge is:
4.0 mm ID × 10 mm length
Packed with 5 µm, 300 Å TYPE‑C™ silica hydride Bidentate C8 phase
Constructed in stainless steel housing with SS frits
The cartridge is supplied in an individual protective Delrin™ case, preventing contamination, drying, and physical damage prior to use.
⚠️ Requires guard column holder (sold separately)
Designed for Standard Analytical Column IDs
This cartridge is optimized for:
3.0 mm ID solvent‑saving HPLC columns
4.0 mm ID analytical columns
4.6 mm ID standard analytical HPLC columns
Ideal for traditional HPLC systems, it ensures:
Minimal band broadening
Maintained chromatographic efficiency
Reliable and reproducible performance
Why Use a Single Guard Cartridge
A single‑cartridge format is ideal when:
Evaluating different guard phases during method development
Pairing multiple stationary phases with different analytical columns
Replacing cartridges individually as needed
Maintaining flexibility without purchasing multi‑packs
This format supports custom method optimization and workflow flexibility.
Why Use 300 Å Guard Cartridges
The 300 Å pore size is specifically designed for:
Peptides and proteins
Large molecular weight analytes
Complex or biological sample matrices
Compared to 100 Å phases:
Improves accessibility for large molecules
Reduces steric exclusion effects
Enhances recovery and reproducibility for biomolecule separations
Why Use Guard Column Protection
Analytical columns are routinely exposed to:
Particulates and insoluble debris
Strongly retained compounds
Sample matrix buildup
Irreversible adsorption
The 40008‑PG6‑3 cartridge acts as a sacrificial protection layer, helping to:
Extend analytical column lifetime
Maintain consistent chromatographic performance
Reduce downtime and replacement costs
Improve reproducibility across analyses
Cartridges can be replaced quickly without disturbing the analytical column.
Bidentate C8 Guard Phase Advantages
Matching the guard phase to your analytical column ensures:
Consistent selectivity and retention behavior
No unexpected method changes
Seamless analyte transfer
Compared to C18 phases, Bidentate C8:
Reduces excessive hydrophobic retention
Improves recovery of amine‑containing analytes
Provides alternative selectivity for complex samples
Supports faster equilibration
Cogent TYPE‑C™ Technology Benefits
Silica Hydride Surface
Reduced silanol interactions
Improved peak shape for basic and polar analytes
Lower secondary interactions
Faster Equilibration
Reduced run‑to‑run cycle times
Increased laboratory throughput
Durability
Resistant to hydrolysis
Long cartridge lifetime
Stable under demanding analytical conditions
Typical Applications
LC‑MS and HPLC biomolecule analysis
Peptide and protein separations
Pharmaceutical and bioanalytical workflows
Complex biological matrices
Wide‑pore chromatography methods
Made‑to‑Order & Pricing Information
This is a custom, made‑to‑order item.
Orders cannot be canceled once placed
Custom items are non‑returnable